The N676D and G697R mutations in the kinase domain of FLT3 confer resistance to the inhibitor AC220.
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چکیده
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منابع مشابه
Crystal Structure of the FLT3 Kinase Domain Bound to the Inhibitor Quizartinib (AC220)
More than 30% of acute myeloid leukemia (AML) patients possess activating mutations in the receptor tyrosine kinase FMS-like tyrosine kinase 3 or FLT3. A small-molecule inhibitor of FLT3 (known as quizartinib or AC220) that is currently in clinical trials appears promising for the treatment of AML. Here, we report the co-crystal structure of the kinase domain of FLT3 in complex with quizartinib...
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ورودعنوان ژورنال:
- Haematologica
دوره 97 11 شماره
صفحات -
تاریخ انتشار 2012